Hypothalamic involvement in premature aging laminopathies
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چکیده
منابع مشابه
Hypothalamic involvement in premature aging laminopathies
Caloric restriction (CR), the reduced intake of calories without malnutrition, extends lifespan of many organisms, from yeast to mammals, and delays the progression of age-related diseases. Evidence show that hypothalamus is a crucial brain region for the progress of whole-body aging [1] and the beneficial effects induced by CR are regulated by nutrient-sensing neurons located in the hypothalam...
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Lamin A/C gene mutations can be associated with myocardial diseases, usually characterized by dilated cardiomyopathy and/or arrhythmic disorders. Phenotypic penetrance is age-related but expression is extremely heterogeneous, so that muscular and arrhythmic disease can be present in combination in the same patient, or one phenotypic manifestation can appear earlier than the other or even not be...
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It has been demonstrated that nuclear lamins are important proteins in maintaining cellular as well as nuclear integrity, and in maintaining chromatin organization in the nucleus. Moreover, there is growing evidence that lamins play a prominent role in transcriptional control. The family of laminopathies is a fast-growing group of diseases caused by abnormalities in the structure or processing ...
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There is now general agreement that the central nervous system, or, more particularly, the hypothalamus, is capable of stimulating the anterior pituitary gland to secrete adrenocorticotrophic hormone (ACTH) whenever the individual is exposed to a stressing agent. This ACTH, by its effect on the adrenal cortical secretion, brings about the adaptation of the body (general adaptation syndrome). On...
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ژورنال
عنوان ژورنال: Orphanet Journal of Rare Diseases
سال: 2015
ISSN: 1750-1172
DOI: 10.1186/1750-1172-10-s2-o6